Empirical Clinical Studies

Recent Publications

Milrod, B. Psychodynamic Psychotherapy Outcome for Generalized Anxiety Disorder. Editorial. American Journal of Psychiatry (in press, 2009).

Busch, FN, Milrod,B, Sandberg,L: A study demonstrating efficacy of a psychoanalytic psychotherapy for panic disorder: implications for psychoanalytic research, theory, and practice, JAPA (in press, 2009)

Sneed, J. R., Keilp, J. G., Brickman, A. M., & Roose, S. P. (2008). The specificity of neuropsychological impairment in predicting antidepressant non-response in the very old depressed. International Journal of Geriatric Psychiatry, 23(3), 319-323.

Sneed, J. R., Rutherford, B. R., Rindskopf, D., Lane, D. T., Sackeim, H. A., & Roose, S. P. (2008). Design makes a difference: A meta-analysis of antidepressant response rates in placebo-controlled versus comparator trials in late-life depression. American Journal of Geriatric Psychiatry, 16(1), 65-73.

Milrod, B. (2007b). "A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder": Dr. Milrod replies. American Journal of Psychiatry, 164(6), 977.

Milrod, B., Leon, A. C., Busch, F., Rudden, M., Schwalberg, M., Clarkin, J., et al. (2007b). "A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder": Erratum. American Journal of Psychiatry, 164(3), 529.

Clarkin, J. F., Levy, K. N., Lenzenweger, M. F., & Kernberg, O. F. (2007). Evaluating three treatments for borderline personality disorder: A multiwave study. American Journal of Psychiatry, 164(6), 922-928.

Fertuck, E. A. (2007). Review of Evidence-based Psychotherapy: Where Theory and Practice Meet. Psychotherapy: Theory, Research, Practice, Training, 44(1), 115-116.

Leon, A. C., Busch, F., Rudden, M., Schwalberg, M., Clarkin, J., Aronson, A., et al. (2007). A Randomized Controlled Clinical Trial of Psychoanalytic Psychotherapy for Panic Disorder: Erratum. American Journal of Psychiatry, 164(7), 1123.

Milrod, B. L., Leon, A. C., Barber, J. P., Markowitz, J. C., & Graf, E. (2007). Do comorbid personality disorders moderate panic-focused psychotherapy? An exploratory examination of the American Psychiatric Association practice guideline. Journal of Clinical Psychiatry, 68(6), 885-891.

Milrod, B., Leon, A. C., Busch, F., Rudden, M., Schwalberg, M., Clarkin, J., et al. (2007a). A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder. American Journal of Psychiatry, 164(2), 265-272.

Nelson, J., Holden, K., Roose, S., Salzman, C., Hollander, S. B., & Betzel, J. V. (2007). Are there predictors of outcome in depressed elderly nursing home residents during treatment with mirtazapine orally disintegrating tablets? International Journal of Geriatric Psychiatry, 22(10), 999-1003.

Rutherford, B., Sneed, J., Miyazaki, M., Eisenstadt, R., Devanand, D., Sackeim, H., et al. (2007). An open trial of aripiprazole augmentation for SSRI non-remitters with late-life depression. International Journal of Geriatric Psychiatry, 22(10), 986-991.

Sneed, J. R., Roose, S. P., Keilp, J. G., Krishnan, K., Alexopoulos, G. S., & Sackeim, H. A. (2007). Response inhibition predicts poor antidepressant treatment response in very old depressed patients. American Journal of Geriatric Psychiatry, 15(7), 553-563.

Yeomans, F. (2007). Questions concerning the randomized trial of schema-focused therapy vs transference-focused psychotherapy. Archives of General Psychiatry, 64(5), 609-610.

Seidman, S. N., & Roose, S. P. (2006). The Sexual Effects of Testosterone Replacement in Depressed Men: Randomized, Placebo-Controlled Clinical Trial. Journal of Sex & Marital Therapy, 32(3), 267-273.

Seidman, S. N., Miyazaki, M., & Roose, S. P. (2005). Intramuscular testosterone supplementation to selective serotonin reuptake inhibitor in treatment-resistant depressed men: Randomized placebo-controlled clinical trial. Journal of Clinical Psychopharmacology, 25(6), 584-588.

Works in Progress

Comparative Outcomes of Psychotherapy and Psychoanalysis Study

Primary Researchers: Steven Roose, M.D., Robert Glick, M.D., Andrew Gerber, M.D., Eve Caligor, M.D., and Bret Rutherford, M.D.

The study aims to measure and compare the effects of cognitive behavioral therapy, supportive-expressive psychotherapy, and psychoanalysis as treatment for chronic, complicated depression. Primary outcomes will be assessed with a variety of instruments measuring symptom level, global functioning, and interpersonal relationships. Utilizing expert researchers in each of the various fields, the COPPS study has garnered support from other institutions and should ultimately yield unprecedented findings.

Assessment of Personality Organization, Depression and Anxiety in Patients Evaluated for Psychoanalysis

Primary Researcher: Eve Caligor, M.D.

This study examines the factors that contribute to patients being accepted or rejected for analytic treatment. There is also an observation of the fate of psychiatric symptoms and personality traits during analysis. Patients are administered structured intake interviews such as but not exclusive to the SCIDs, Hamiltons, and STIPOs as well as self-report questionnaires at baseline, and follow-up self-reports at 3, 6 and 12 months. Patients, candidates, and supervisors are surveyed on their impressions of the effect the research study has on the integrity of the analysis.

Structured Interview for Personality Organization: Test-retest Reliability and Temporal Stability

Primary Researcher: Barry Stern, Ph.D.

The Structured Interview of Personality Organization (STIPO) was developed to provide a dimensional assessment of features that, according to modern object relations theory, are thought to underlie personality disorders. The purpose of Dr. Stern’s study is to assess the reliability properties of the STIPO, specifically, scale internal consistency, inter-rater reliability, 4-week test-retest reliability, and 4-month temporal stability. The constructs operationalized in the STIPO are hypothesized as deriving from mental representations of self and others that are presumed to be stable over time. Repeated measurements of the STIPO domains over a relatively brief period of time would therefore provide an assessment of measurement error in the interview itself; re-assessment, as proposed at 4 months, would provide an estimate of temporal stability for the constructs assessed in the STIPO. The protocol was approved by the NYSPI IRB in September 2007, and the study is now in the recruitment/research phase.